Weill Cornell Medical College Research Technician II - Antibody Generation in New York, New York

Position Summary

With minimal supervision, designs and carries out experiments to generate and characterize therapeutic monoclonal antibodie, both in vivo by immunizing mice and conducting hybridoma fusions, and in vitro by phage display panning.

Job Responsibilities

  • Conducts immunizations and bleeding of mice.

  • Performs hybridoma fusions.

  • Generates and maintains hybridoma cell lines that produce monoclonal antibodies.

  • Carries out phage display panning selections.

  • Screens phage pools for binders to target antigens by ELISA.

  • Collaborates with the in-house monoclonal antibody core facility for in vivo antibody generation efforts.

  • Keeps a detailed and well organized laboratory notebook.

  • Presents project updates at group meetings.

  • Stays current with literature and emerging trends in the discipline.

  • Performs other related duties as assigned.


  • Bachelor's Degree in related field


Bachelor’s degree in immunology, molecular biology, microbiology or related field.

Master’s degree in immunology, molecular biology, microbiology, or related field is highly desired.

A minimum of 3 years of experience in antibody generation in an academic laboratory, or in the pharmaceutical or biotechnology industry.

Demonstrated track record with publications or patents.

Must be comfortable with animal handling and skilled in rodent immunizations and manipulations.

Experience in preparation of antigens for immunization of animals.

Expertise in hybridoma generation, cloning and maintenance.

Sterile tissue culture technique.

Proficiency with enzyme-linked immunosorbent assay (ELISA).

Basic skills in molecular biology (PCR, plasmid preparation, DNA sequence analysis), and with handling and manipulating microbial cultures.

Experience with phage display panning techniques a plus.

Knowledge, Skills and Abilities

  • Ability to work on multiple projects simultaneously to deliver results in rapid timeframes.

  • Critical independent thinking, prioritization of tasks, strong problem-solving and troubleshooting, and excellent communication and presentation skills.

  • Timely delivery of team goals and ability to build productive relationships with colleagues and collaborators.

Licenses and Certifications

Working Conditions/Physical Demands

Weill Cornell Medicine is a comprehensive academic medical center that's committed to excellence in patient care, scientific discovery, and the education of future physicians in New York City and around the world. Our doctors and scientists-faculty from Weill Cornell Medical College, Weill Cornell Graduate School of Medical Sciences, and the Weill Cornell Physician Organization-are engaged in world-class clinical care and cutting-edge research that connect patients to the latest treatment innovations and prevention strategies. Located in the heart of the Upper East Side's scientific corridor, Weill Cornell Medicine's powerful network of collaborators extends to its parent university Cornell University; to Qatar, where an international campus offers a U.S. medical degree; and to programs in Tanzania, Haiti, Brazil, Austria and Turkey. Our medical practices serve communities throughout New York City, and our faculty provide comprehensive care at NewYork-Presbyterian Hospital/Weill Cornell Medical Center, NewYork-Presbyterian/Lower Manhattan Hospital, and NewYork-Presbyterian/Queens. At Weill Cornell Medicine, we work together to treat each individual, not just their conditions or illnesses, as we strive to deliver the finest possible care for our patients - the center of everything we do. Weill Cornell Medicine is an Equal Employment Opportunity/Minorities/Females/Vet/Disabled employer.